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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
21.82
Human Site:
T286
Identified Species:
36.92
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
T286
V
E
G
D
A
A
E
T
P
P
R
P
R
T
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
T286
V
E
G
D
A
A
E
T
P
P
R
P
R
T
P
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
T286
V
E
G
D
A
A
E
T
P
P
R
P
R
T
P
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
T286
V
E
G
D
A
A
E
T
P
P
R
P
R
T
P
Rat
Rattus norvegicus
Q01986
393
43447
T286
V
E
G
D
A
A
E
T
P
P
R
P
R
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
T302
V
E
G
D
A
S
E
T
S
P
P
M
A
I
F
Chicken
Gallus gallus
Q90891
398
44059
V292
A
E
G
E
S
H
S
V
S
P
W
A
R
P
P
Frog
Xenopus laevis
Q05116
395
43724
L288
R
D
P
A
S
S
E
L
A
P
R
P
R
P
P
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
D266
K
G
Y
N
V
K
S
D
I
W
S
L
G
I
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
E300
I
F
A
D
N
A
E
E
S
G
Q
P
T
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
N285
T
M
F
N
V
A
E
N
E
I
E
L
A
D
S
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
A302
L
F
G
Y
E
L
Q
A
G
E
T
K
N
I
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
T275
A
P
P
N
Q
E
E
T
W
T
S
V
F
E
L
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
A578
N
I
F
S
Q
L
S
A
I
V
D
G
P
P
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
53.3
33.3
40
0
N.A.
26.6
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
60
46.6
60
6.6
N.A.
40
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
8
8
43
50
0
15
8
0
0
8
15
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
50
0
0
0
8
0
0
8
0
0
15
0
% D
% Glu:
0
50
0
8
8
8
72
8
8
8
8
0
0
8
8
% E
% Phe:
0
15
15
0
0
0
0
0
0
0
0
0
8
0
8
% F
% Gly:
0
8
58
0
0
0
0
0
8
8
0
8
8
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
0
0
15
8
0
0
0
22
0
% I
% Lys:
8
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% K
% Leu:
8
0
0
0
0
15
0
8
0
0
0
15
0
0
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
0
0
22
8
0
0
8
0
0
0
0
8
0
0
% N
% Pro:
0
8
15
0
0
0
0
0
36
58
8
50
8
22
58
% P
% Gln:
0
0
0
0
15
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
43
0
50
0
8
% R
% Ser:
0
0
0
8
15
15
22
0
22
0
15
0
0
0
8
% S
% Thr:
8
0
0
0
0
0
0
50
0
8
8
0
8
36
8
% T
% Val:
43
0
0
0
15
0
0
8
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
8
8
0
0
0
0
% W
% Tyr:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _